Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360591 | 0.89 | CXCL8 (0.65) | CXCL8MAPTALOX15FABP4MEN1 | |
| SCHEMBL16539266 | 0.86 | CXCL8 (0.64) | CXCL8MAPTALOX15FABP4MEN1 | |
| SCHEMBL27779016 | 0.81 | CXCR2 (0.46) | CXCL8MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27800291 | 0.81 | MEN1 (0.48) | CXCL8MAPTALOX15MEN1KMT2A | |
| SCHEMBL27779943 | 0.79 | CXCL8 (0.45) | CXCL8MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL7979001 | 0.79 | TDP1 (0.50) | MAPTALOX15FABP4MEN1KMT2A | |
| SCHEMBL27800317 | 0.76 | DHODH (0.56) | MAPTMEN1KMT2AALDH1A1RXFP1 | |
| SCHEMBL30285203 | 0.76 | ALDH1A1 (0.53) | CXCL8MAPTALOX15MEN1KMT2A | |
| SCHEMBL31310572 | 0.75 | MAPT (0.42) | CXCL8MAPTALOX15FABP4MEN1 | |
| SCHEMBL20385231 | 0.75 | MAPT (0.50) | MAPTALOX15FABP4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679270-B | Dihydroquinone and dihydronaphthyridine inhibitors of JNK | HOFFMANN LA ROCHE | 2013-05-01 | — | — | CN | disclosed |
| CN-101679270-A | Dihydroquinone and dihydronaphthyridine inhibitors of JNK | HOFFMANN LA ROCHE | 2010-03-24 | — | — | CN | disclosed |