Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27752188 | 0.83 | WRN (0.40) | WRNMAPTTP53SMN1; SMN2THRB | |
| SCHEMBL27586775 | 0.79 | ALOX5 (0.37) | MAPTSMN1; SMN2THRBALDH1A1HPGD | |
| SCHEMBL27716081 | 0.78 | WRN (0.40) | WRNMAPTTP53SMN1; SMN2THRB | |
| SCHEMBL27708206 | 0.77 | GSK3B (0.36) | WRN | |
| SCHEMBL27752111 | 0.75 | GABBR2 (0.39) | WRN | |
| SCHEMBL27708354 | 0.75 | WRN (0.31) | WRN | |
| SCHEMBL27804135 | 0.74 | HPGD (0.41) | WRNMAPTTP53SMN1; SMN2THRB | |
| SCHEMBL27593353 | 0.70 | NPSR1 (0.43) | MAPTTP53SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2737323 | 0.69 | WRN (0.41) | WRNMAPTTP53SMN1; SMN2THRB | |
| SCHEMBL14507024 | 0.66 | WRN (0.42) | WRNMAPTTP53SMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679388-A | Novel 4-heteroaryl-imidazole-2-thiones used as tyrosinase inhibitors, method for preparing same and use thereof in human medicine and cosmetology | GALDERMA RES & DEV | 2010-03-24 | — | — | CN | disclosed |