SCHEMBL27804530

SCHEMBL27804530

CN(Cc1c[c]ccc1)C(=O)OCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.48
CHRNB4 P30926 1/20 0.48
CHRNA3 P32297 1/20 0.48
CHRNA4 P43681 1/20 0.48
ALDH1A1 P00352 4/20 0.45
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
CA12 O43570 1/20 0.43
CA9 Q16790 1/20 0.43
MAPT P10636 1/20 0.43
HPGD P15428 1/20 0.43
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
LMNA P02545 1/20 0.41
F13A1 P00488 1/20 0.41
TGM2 P21980 1/20 0.41
TGM1 P22735 1/20 0.41
HCAR2 Q8TDS4 1/20 0.41
MAPK1 P28482 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27825262 0.86 CHRNB2 (0.57) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL13687204 0.85 CHRNB2 (0.61) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL206007 0.77 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL20683501 0.77 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL1901573 0.77 CHRNB2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL7367495 0.77 ALDH1A1 (0.58) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL12162097 0.77 NSD2 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4NPC1
SCHEMBL10107202 0.76 ALDH1A1 (0.56) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL205522 0.75 CHRNB2 (0.51) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL16980507 0.75 MEN1 (0.68) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101998959-B Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) BIOMARIN PHARM INC 2013-08-28 CN disclosed
CN-101998959-A Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) LEAD THERAPEUTICS INC 2011-03-30 CN disclosed