Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 7/20 | 0.35 |
| ▸ | PDE1A | P54750 | 5/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807931 | 0.91 | PIK3CA (0.43) | PIK3CA | |
| SCHEMBL27807942 | 0.90 | PIK3CA (0.42) | PIK3CA | |
| SCHEMBL27785957 | 0.88 | PIK3CA (0.39) | PIK3CA | |
| SCHEMBL27807913 | 0.82 | BRD9 (0.36) | PIK3CA | |
| SCHEMBL27786011 | 0.80 | BRD9 (0.36) | PIK3CA | |
| SCHEMBL27785960 | 0.79 | PIK3CA (0.35) | PIK3CA | |
| SCHEMBL2660408 | 0.79 | PDE1B (0.38) | PDE1BPDE1APDE1CPIK3CAPDE5A | |
| SCHEMBL27785937 | 0.78 | ADORA2A (0.32) | — | |
| SCHEMBL27786000 | 0.78 | MAPK10 (0.36) | PIK3CA | |
| SCHEMBL2660334 | 0.78 | PIK3CA (0.39) | PDE1BPDE1APDE1CPIK3CAPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |