Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.36 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 5/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807930 | 0.96 | MAPK10 (0.36) | MAPK10JUNMTORAKT1PIK3CA | |
| SCHEMBL27807904 | 0.87 | PIK3CA (0.42) | MTORAKT1PIK3CA | |
| SCHEMBL27786093 | 0.85 | LCK (0.30) | LCKBTK | |
| SCHEMBL27807944 | 0.84 | AKT1 (0.30) | MTORAKT1 | |
| SCHEMBL27785941 | 0.84 | — | — | |
| SCHEMBL27785985 | 0.84 | CRHR1 (0.30) | — | |
| SCHEMBL27807920 | 0.84 | HSP90AA1 (0.35) | MAPK10JUNMTORPIK3CALCK | |
| SCHEMBL27807925 | 0.83 | GBA1 (0.34) | HSP90AA1 | |
| SCHEMBL27807942 | 0.81 | PIK3CA (0.42) | MTORPIK3CABTK | |
| SCHEMBL27785937 | 0.81 | ADORA2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |