Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.36 |
| ▸ | JUN | P05412 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 5/20 | 0.35 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786000 | 0.96 | MAPK10 (0.36) | MAPK10JUNMTORAKT1LCK | |
| SCHEMBL27807925 | 0.87 | GBA1 (0.34) | HSP90AA1 | |
| SCHEMBL27807920 | 0.85 | HSP90AA1 (0.35) | MAPK10JUNMTORLCKBTK | |
| SCHEMBL27807904 | 0.85 | PIK3CA (0.42) | MTORAKT1PIK3CA | |
| SCHEMBL27807916 | 0.83 | ACHE (0.31) | — | |
| SCHEMBL27785931 | 0.83 | — | — | |
| SCHEMBL27786020 | 0.82 | LCK (0.34) | MAPK10JUNLCKBTKHSP90AA1 | |
| SCHEMBL27786093 | 0.81 | LCK (0.30) | LCKBTK | |
| SCHEMBL27785952 | 0.81 | PIK3CA (0.40) | PIK3CA | |
| SCHEMBL27785935 | 0.80 | MAPK1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |