Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.42 |
| ▸ | MTOR | P42345 | 9/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786000 | 0.87 | MAPK10 (0.36) | PIK3CAMTORAKT1 | |
| SCHEMBL27807929 | 0.87 | PIK3CA (0.34) | PIK3CAMTOR | |
| SCHEMBL27807913 | 0.85 | BRD9 (0.36) | PIK3CA | |
| SCHEMBL27807930 | 0.85 | MAPK10 (0.36) | PIK3CAMTORAKT1 | |
| SCHEMBL27785948 | 0.85 | GABRG2 (0.34) | PIK3CAMTOR | |
| SCHEMBL27807921 | 0.84 | CHRNB1 (0.37) | PIK3CAAKT1 | |
| SCHEMBL27786011 | 0.84 | BRD9 (0.36) | PIK3CA | |
| SCHEMBL28784328 | 0.83 | PIK3CA (0.38) | PIK3CAMTORAKT1 | |
| SCHEMBL27785974 | 0.83 | GABRG2 (0.33) | PIK3CAMTOR | |
| SCHEMBL27786149 | 0.83 | PIK3CA (0.42) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |