Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786050 | 0.88 | GABRG2 (0.35) | GABRG2GABRB3GABRA2KDM1AKDM4E | |
| SCHEMBL27807912 | 0.88 | CD274 (0.36) | GABRG2GABRB3GABRA2MEN1KMT2A | |
| SCHEMBL28784319 | 0.87 | GABRG2 (0.39) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785933 | 0.86 | GABRG2 (0.33) | GABRG2GABRB3GABRA2KDM1A | |
| SCHEMBL27807932 | 0.86 | GABRG2 (0.41) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785971 | 0.86 | GABRG2 (0.33) | GABRG2GABRB3GABRA2ABCG2KDM1A | |
| SCHEMBL28787439 | 0.84 | GABRG2 (0.36) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807958 | 0.84 | GABRG2 (0.36) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807963 | 0.81 | GABRG2 (0.50) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807926 | 0.81 | ALDH1A1 (0.31) | GABRG2GABRB3GABRA2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |