SCHEMBL2780884

SCHEMBL2780884

NC(=O)CC[C@H](N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 1/20 0.39
▸ DPP8 Q6V1X1 1/20 0.39
▸ DPP9 Q86TI2 1/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ BLM P54132 1/20 0.39
▸ PMP22 Q01453 1/20 0.39
▸ MME P08473 1/20 0.36
▸ ECE1 P42892 1/20 0.36
▸ BACE1 P56817 3/20 0.35
▸ CA2 P00918 2/20 0.34
▸ CA1 P00915 1/20 0.34
▸ NPY1R P25929 1/20 0.33
▸ NPY2R P49146 1/20 0.33
▸ NPY4R P50391 1/20 0.33
▸ HDAC3 O15379 1/20 0.33
▸ HDAC4 P56524 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC7 Q8WUI4 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5970335 1.00 DPP4 (0.39) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL29630385 0.97 BACE1 (0.39) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL29630656 0.94 DPP4 (0.35) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL29630607 0.93 MME (0.38) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL31482979 0.93 MME (0.38) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL29590459 0.93 MME (0.38) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL17768459 0.92 DPP4 (0.40) DPP4DPP8DPP9BACE1HDAC3
SCHEMBL2780879 0.92 DPP4 (0.40) DPP4DPP8DPP9BACE1HDAC3
SCHEMBL30272504 0.91 BACE1 (0.37) DPP4DPP8DPP9KMT2AALOX15
SCHEMBL5970125 0.91 KMT2A (0.40) DPP4DPP8DPP9KMT2AALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11576946-B2 Peptidyl inhibitors of calcineurin-NFAT interaction OHIO STATE INNOVATION FOUNDATION (US) 2023-02-14 — — US claimed
US-20220289846-A1 ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 ZYDUS LIFESCIENCES LIMITED (IN) 2022-09-15 — — US claimed
EP-3997126-A1 ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 Cadila Healthcare Limited (IN) 2022-05-18 — — EP claimed
US-20260077012-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES EPITRACKER INC (US) 2026-03-19 — — US disclosed
US-12516121-B2 Antibodies to human programmed death receptor PD-1 ZYDUS LIFESCIENCES LIMITED (IN) 2026-01-06 — — US disclosed
US-20250336540-A1 METABOLITE PREDICTORS FOR LUNG CANCER JANSSEN PHARMACEUTICA NV (BE) 2025-10-30 — — US disclosed
US-12427179-B2 Compositions and methods for diagnosis and treatment of neurodegenerative diseases Epitracker, Inc. (US) 2025-09-30 — — US disclosed
US-12329799-B2 Peptidyl inhibitors of calcineurin-NFAT interaction OHIO STATE INNOVATION FOUNDATION (US) 2025-06-17 — — US disclosed
US-20240033318-A1 PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION OHIO STATE INNOVATION FOUNDATION 2024-02-01 — — US disclosed
US-20230390346-A1 PROBIOTIC BACILLUS COMPOSITIONS AND METHODS OF USE BIOMEDIT, LLC 2023-12-07 — — US disclosed
WO-2023209218-A1 METABOLITE PREDICTORS FOR LUNG CANCER JANSSEN PHARMACEUTICA NV (BE) 2023-11-02 — — WO disclosed
US-20190310269-A1 SYSTEMS AND METHODS FOR MEASURING OBESITY USING METABOLOME ANALYSIS HUMAN LONGEVITY, INC. 2019-10-10 — — US disclosed
WO-2019055718-A1 METABOLOMIC REVISION OF MAMMALIAN INFANTS Evolve Biosystems, Inc. (US) 2019-03-21 — — WO disclosed
US-20180320217-A1 METHODS FOR SAMPLING AND MEASURING ORAL LAVAGE PROTEINS THE PROCTER & GAMBLE COMPANY 2018-11-08 — — US disclosed
US-20170370954-A1 Biomarkers for Fatty Liver Disease and Methods Using the Same METABOLON, INC. 2017-12-28 — — US disclosed
EP-3221463-A1 BIOMARKERS FOR FATTY LIVER DISEASE AND METHODS USING THE SAME Metabolon, Inc. (US) 2017-09-27 — — EP disclosed
WO-2016081534-A1 BIOMARKERS FOR FATTY LIVER DISEASE AND METHODS USING THE SAME METABOLON, INC. (US) 2016-05-26 — — WO disclosed
US-20100323975-A1 THERAPEUTIC AGENT FOR CEREBRAL ISCHEMIC INJURY OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 2010-12-23 — — US disclosed
EP-2228068-A1 THERAPEUTIC AGENT FOR CEREBRAL ISCHEMIC INJURY Otsuka Pharmaceutical Factory, Inc. (JP) 2010-09-15 — — EP disclosed
US-20060217321-A1 Compositions to improve tic disorders TAIYOKAGAKU CO., LTD. (JP) 2006-09-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260077012-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES CD4, COL2A1, MMP1 DPP4 3107/4885DPP8 1167/4885DPP9 1915/4885
US-12329799-B2 Peptidyl inhibitors of calcineurin-NFAT interaction CHP1, NFATC1, PPP3R1 DPP4 1877/4885DPP8 2336/4885DPP9 2337/4885
US-20240033318-A1 PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION CHP1, NFATC1, PPP3R1 DPP4 1877/4885DPP8 2336/4885DPP9 2337/4885
US-11576946-B2 Peptidyl inhibitors of calcineurin-NFAT interaction CHP1, NFATC1, PPP3R1 DPP4 1877/4885DPP8 2336/4885DPP9 2337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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