Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 2/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756847 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL10586443 | 0.90 | CTSS (0.51) | KDM4EALDH1A1TSHRHSD17B10HRH4 | |
| Leucine SCHEMBL1406254 | 0.89 | MMP2 (0.50) | KDM4EALDH1A1TSHRHSD17B10POLB | |
| SCHEMBL9631257 | 0.89 | POLB (0.53) | KDM4EALDH1A1TSHRHSD17B10POLB | |
| Leucine SCHEMBL3812226 | 0.87 | MMP2 (0.48) | KDM4EALDH1A1TSHRHSD17B10MME | |
| SCHEMBL233988 | 0.87 | MMP2 (0.48) | KDM4EALDH1A1TSHRHSD17B10HRH4 | |
| Leucine SCHEMBL5528909 | 0.87 | MMP2 (0.48) | KDM4EALDH1A1TSHRHSD17B10POLB | |
| Leucine SCHEMBL8202526 | 0.86 | MMP2 (0.48) | KDM4EALDH1A1TSHRHSD17B10POLB | |
| Leucine SCHEMBL2297615 | 0.86 | MMP2 (0.49) | KDM4EALDH1A1TSHRHSD17B10HRH4 | |
| SCHEMBL7272341 | 0.85 | SMN1; SMN2 (0.55) | KDM4EALDH1A1HRH4MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258680-B1 | Aromatic derivatives as HIV aspartyl protease inhibitors | TAIMED BIOLOG INC (TW) | 2012-09-19 | — | — | EP | disclosed |
| EP-2258680-A2 | Aromatic derivatives as HIV aspartyl protease inhibitors | Ambrilia Biopharma Inc. (CA) | 2010-12-08 | — | — | EP | disclosed |
| EP-2258681-A2 | Aromatic Derivatives as HIV Aspartyl Protease Inhibitors | Ambrilia Biopharma Inc. (CA) | 2010-12-08 | — | — | EP | disclosed |
| EP-1575914-A1 | AROMATIC DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | Procyon Biopharma Inc. (CA) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004056764-A1 | AROMATIC DERIVATIVES AS HIV ASPARTYL PROTEASE INHIBITORS | PROCYON BIOPHARMA INC. (CA) | 2004-07-08 | — | — | WO | disclosed |
| US-6632816-B1 | Aromatic derivatives as HIV aspartyl protease inhibitors | PHARMACOR INC. (CA) | 2003-10-14 | — | — | US | disclosed |