Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.54 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.53 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275612 | 0.87 | TACR1 (0.58) | ALDH1A1KDM4EMAPTHTTGAA | |
| SCHEMBL7288345 | 0.85 | ALDH1A1 (0.63) | LMNAALDH1A1KDM4EMAPTNPFFR1 | |
| SCHEMBL756847 | 0.85 | KDM4E (0.55) | ALDH1A1KDM4EMAPTGAAMMP2 | |
| SCHEMBL2780950 | 0.85 | KDM4E (0.55) | ALDH1A1KDM4EMAPTGAAMMP2 | |
| SCHEMBL2632588 | 0.84 | USP2 (0.61) | SMN1; SMN2LMNAALDH1A1MAPTPSMB8 | |
| SCHEMBL18964686 | 0.80 | HTT (0.59) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL17706113 | 0.80 | HTT (0.59) | SMN1; SMN2LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL8671488 | 0.79 | HRH4 (0.60) | TDP1MMP2MMP9MMP8HRH4 | |
| SCHEMBL3662089 | 0.79 | HRH4 (0.60) | TDP1MMP2MMP9MMP8HRH4 | |
| SCHEMBL3662085 | 0.79 | HRH4 (0.60) | TDP1MMP2MMP9MMP8HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| US-5364844-A | Hypotensive agents | SANKYO COMPANY, LIMITED (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0274259-B1 | New renin-inhibitory oligopeptides, their preparaton and their use | SANKYO CO (JP) | 1994-02-16 | — | — | EP | disclosed |
| EP-0326364-A2 | Renin inhibitory oligopeptides, their preparation and use | Sankyo Company Limited (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |