Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246147 | 0.87 | PLA2G4A (0.45) | TLR7HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL1246665 | 0.82 | RAB9A (0.59) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL27830319 | 0.79 | TLR7 (0.54) | TLR7HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL22222465 | 0.76 | KDM4E (0.41) | TLR7HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL17115621 | 0.74 | KMT2A (0.40) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL13909940 | 0.74 | KDM1A (0.38) | TLR7HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL23717206 | 0.74 | PLA2G4A (0.41) | MAPTALDH1A1NPC1RAB9ACYP2C19 | |
| SCHEMBL2754047 | 0.73 | TLR7 (0.49) | TLR7HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL3549501 | 0.72 | SMN1; SMN2 (0.41) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL16503356 | 0.71 | PLA2G4A (0.44) | TLR7HDAC1HDAC8HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102625808-B | Spirocyclic amide derivatives | ASTRAZENECA AB | 2014-08-27 | — | — | CN | disclosed |
| CN-102625808-A | Spirocyclic amide derivatives | ASTRAZENECA AB | 2012-08-01 | — | — | CN | disclosed |
| CN-102083839-A | Compound (I) | ASTRAZENECA AB | 2011-06-01 | — | — | CN | disclosed |