Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 6/20 | 0.46 |
| ▸ | TACR3 | P29371 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27810157 | 0.82 | TSHR (0.41) | LMNAHPGDSMN1; SMN2KDM4EDHODH | |
| SCHEMBL29245619 | 0.78 | SMN1; SMN2 (0.60) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28041155 | 0.76 | LMNA (0.65) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27810074 | 0.75 | MAPT (0.49) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1898878 | 0.75 | DHODH (0.62) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1899209 | 0.74 | DHODH (0.76) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4857792 | 0.73 | LMNA (0.54) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4204786 | 0.73 | LMNA (0.64) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10866597 | 0.70 | TP53 (0.57) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9319078 | 0.70 | MAPT (0.57) | LMNAHPGDSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102099352-B | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INC ASS | 2014-02-26 | — | — | CN | disclosed |
| CN-102099352-A | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INC ASS | 2011-06-15 | — | — | CN | disclosed |