Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27507137 | 0.80 | MAPT (0.58) | MAPTHTTALDH1A1POLBKDM4E | |
| SCHEMBL28195451 | 0.77 | CYP19A1 (0.48) | MAPTALDH1A1POLBKDM4ELMNA | |
| SCHEMBL7746134 | 0.76 | CASP1 (0.45) | MAPTHTTALDH1A1POLBKDM4E | |
| SCHEMBL27729998 | 0.76 | SMN1; SMN2 (0.43) | MAPTHTTALDH1A1POLBKDM4E | |
| SCHEMBL27810066 | 0.75 | LMNA (0.47) | MAPTHTTALDH1A1KDM4ELMNA | |
| SCHEMBL27810157 | 0.75 | TSHR (0.41) | POLBKDM4ELMNAHPGDKMT2A | |
| SCHEMBL11806239 | 0.75 | SMN1; SMN2 (0.46) | MAPTHTTALDH1A1POLBKDM4E | |
| SCHEMBL26607243 | 0.75 | SMN1; SMN2 (0.51) | MAPTHTTKDM4ELMNANPC1 | |
| SCHEMBL27508841 | 0.73 | KDM4E (0.50) | MAPTHTTALDH1A1POLBKDM4E | |
| SCHEMBL3290432 | 0.73 | HSD17B10 (0.56) | ALDH1A1KDM4ELMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102099352-B | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INC ASS | 2014-02-26 | — | — | CN | disclosed |
| CN-102099352-A | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INC ASS | 2011-06-15 | — | — | CN | disclosed |