Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.48 |
| ▸ | CTSL | P07711 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29060746 | 0.87 | CTSK (0.47) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL28220061 | 0.87 | NPC1 (0.43) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL27794800 | 0.87 | CTSK (0.49) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL15311168 | 0.87 | CTSK (0.49) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL14716956 | 0.87 | CTSK (0.49) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL28563934 | 0.85 | EPHX2 (0.40) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL27580044 | 0.84 | PPARA (0.46) | SCN9ANPC1RAB9AMAPTCTSS | |
| SCHEMBL28404852 | 0.84 | CTSK (0.45) | CTSKCTSLCTSBSCN9ANPC1 | |
| SCHEMBL19385529 | 0.84 | CTSK (0.48) | CTSKCTSLCTSBNPC1RAB9A | |
| SCHEMBL28520879 | 0.83 | CTSK (0.52) | CTSKCTSLCTSBSCN9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104053661-B | The thienopyrimidines inhibitor of atypical protein kinase C | 癌症研究技术有限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-104053661-A | Thienopyrimidine Inhibitors Of Atypical Protein Kinase C | CANCER REC TECH LTD | 2014-09-17 | — | — | CN | disclosed |
| CN-102112130-A | Pyrazine derivatives as epithelial sodium channel blockers | NOVARTIS AG | 2011-06-29 | — | — | CN | disclosed |