Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27812309 | 0.87 | CTSK (0.48) | NPC1RAB9ASCN9ACTSLCTSB | |
| SCHEMBL28563934 | 0.86 | EPHX2 (0.40) | NPC1RAB9ASMN1; SMN2SCN9ACTSL | |
| SCHEMBL28563949 | 0.76 | OPRD1 (0.42) | PPARGPPARAALDH1A1 | |
| SCHEMBL29096483 | 0.75 | TRPA1 (0.43) | SMN1; SMN2HPGDSCN9ACTSLCTSB | |
| SCHEMBL29060746 | 0.75 | CTSK (0.47) | NPC1RAB9ASCN9ACTSLCTSB | |
| SCHEMBL14716956 | 0.74 | CTSK (0.49) | NPC1RAB9ASCN9ACTSLCTSB | |
| SCHEMBL27794800 | 0.74 | CTSK (0.49) | NPC1RAB9ASCN9ACTSLCTSB | |
| SCHEMBL15311168 | 0.74 | CTSK (0.49) | NPC1RAB9ASCN9ACTSLCTSB | |
| SCHEMBL28913861 | 0.74 | OPRM1 (0.34) | SCN9A | |
| SCHEMBL29271806 | 0.74 | PRKCA (0.37) | MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104053661-B | The thienopyrimidines inhibitor of atypical protein kinase C | 癌症研究技术有限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-104053661-A | Thienopyrimidine Inhibitors Of Atypical Protein Kinase C | CANCER REC TECH LTD | 2014-09-17 | — | — | CN | disclosed |