Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17100669 | 0.90 | CYP2D6 (0.49) | HTTMAPTTSHRHSD17B10MAPK1 | |
| SCHEMBL17115053 | 0.83 | FAAH (0.48) | HTTFAAHNR1H4NOTUM | |
| SCHEMBL14153523 | 0.82 | TP53 (0.47) | HTTNPSR1MAPTTSHRHSD17B10 | |
| SCHEMBL20116402 | 0.82 | MAPT (0.58) | HTTMAPTHSD17B10SMN1; SMN2CYP1A2 | |
| SCHEMBL12490987 | 0.81 | FAAH (0.50) | HTTMAPTSMN1; SMN2FAAHNR1H4 | |
| SCHEMBL12490586 | 0.81 | FAAH (0.47) | NPSR1MAPTHSD17B10MAPK1SMN1; SMN2 | |
| SCHEMBL12506166 | 0.80 | GPR119 (0.51) | HTTMAPTHSD17B10SMN1; SMN2FAAH | |
| SCHEMBL17100583 | 0.78 | CYP2D6 (0.71) | HTTNPSR1MAPTTSHRHSD17B10 | |
| SCHEMBL12490134 | 0.78 | FAAH (0.47) | MAPTSMN1; SMN2FAAHNR1H4LMNA | |
| SCHEMBL29040325 | 0.77 | FAAH (0.47) | HTTMAPTHSD17B10SMN1; SMN2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101883770-A | 6-pyrimidinyl-pyrimid-2-one derivative | MITSUBISHI TANABE PHARMA CORP | 2010-11-10 | — | — | CN | disclosed |
| CN-101842371-A | 3-methyl-2- ( (2s) -2- (4- (3-methyl-l, 2, 4-0xadiaz0l-5-yl) phenyl) morpholino) -6- (pyrimidin-4-yl) pyrimidin-4 (3h) -one as tau protein kinase inhibitor | SANOFI AVENTIS | 2010-09-22 | — | — | CN | disclosed |