Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.59 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | DDX3X | O00571 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGAV | P06756 | 1/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16585276 | 0.84 | NTRK1 (0.74) | NTRK1NTRK3NTRK2NPC1RAB9A | |
| SCHEMBL16585187 | 0.83 | NTRK1 (0.69) | NTRK1NTRK3NTRK2KMT2AMEN1 | |
| SCHEMBL29273709 | 0.80 | MAPT (0.65) | KMT2AMEN1LMNAPPIA | |
| SCHEMBL1275926 | 0.78 | RAB9A (0.75) | NPC1RAB9AKMT2APOLBMEN1 | |
| SCHEMBL16592358 | 0.78 | CA12 (0.63) | NTRK1NTRK3NTRK2RAB9AKMT2A | |
| SCHEMBL16585250 | 0.78 | NTRK1 (0.58) | NTRK1NTRK3NTRK2KMT2AMEN1 | |
| SCHEMBL16585165 | 0.78 | NTRK1 (0.66) | NTRK1NTRK3NTRK2KMT2APOLB | |
| SCHEMBL22873283 | 0.78 | KMT2A (0.61) | KMT2AMEN1LMNAPPIA | |
| SCHEMBL16585359 | 0.76 | NTRK1 (0.71) | NTRK1NTRK3NTRK2KMT2AMEN1 | |
| SCHEMBL1007576 | 0.75 | MAPT (0.62) | KMT2AMEN1LMNAPPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101880246-A | Substituted benzoyl urea compound and preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2010-11-10 | — | — | CN | claimed |
| CN-101880246-B | Substituted benzoyl urea compound and preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2012-10-03 | — | — | CN | disclosed |
| CN-101880246-A | Substituted benzoyl urea compound and preparation method and application thereof | SHANGHAI INST MATERIA MEDICA | 2010-11-10 | — | — | CN | disclosed |