SCHEMBL27820163

SCHEMBL27820163

CNO.NCc1ccc(CN)cc1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ABAT P80404 1/20 0.57
HRH3 Q9Y5N1 1/20 0.55
HDAC3 O15379 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
NCOR2 Q9Y618 1/20 0.54
LOXL2 Q9Y4K0 7/20 0.52
NOS3 P29474 2/20 0.50
NOS1 P29475 2/20 0.50
NOS2 P35228 2/20 0.50
TPSAB1 Q15661 2/20 0.48
F10 P00742 1/20 0.48
F11 P03951 1/20 0.48
TAAR1 Q96RJ0 1/20 0.46
PSIP1 O75475 1/20 0.44
KDM4E B2RXH2 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methyl Alcohol SCHEMBL22528993 0.84 ABAT (0.67) ABATHRH3HDAC3HDAC6NCOR2
SCHEMBL27238704 0.80 HRH3 (0.79) ABATHRH3LOXL2NOS3NOS1
SCHEMBL15828 0.80 HRH3 (0.79) ABATHRH3LOXL2NOS3NOS1
SCHEMBL4865180 0.78 KDM4E (0.54) ABATHRH3LOXL2NOS3NOS1
SCHEMBL12976226 0.78 THRB (0.56) ABATHRH3HDAC3HDAC6NCOR2
SCHEMBL2290799 0.78 HRH3 (0.50) ABATHRH3HDAC3HDAC6NCOR2
SCHEMBL6314683 0.78 HRH3 (0.65) ABATHRH3LOXL2F10F11
Iodide SCHEMBL29191162 0.77 HRH3 (0.73) ABATHRH3LOXL2NOS3NOS1
Iodide SCHEMBL28395414 0.77 HRH3 (0.73) ABATHRH3LOXL2NOS3NOS1
Hydrochloric Acid SCHEMBL3168189 0.77 HRH3 (0.73) ABATHRH3LOXL2NOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102203055-A Nitric oxide releasing amino acid ester compound, composition and method of use NITROGENIX INC 2011-09-28 CN disclosed