Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197407 | 0.88 | HDAC1 (0.41) | GAAPOLBKDM4ENPC1RAB9A | |
| SCHEMBL1711712 | 0.76 | KDM4E (0.47) | POLBKDM4EMEN1NPC1RAB9A | |
| SCHEMBL25752898 | 0.74 | RAB9A (0.50) | GAAPOLBKDM4EMEN1NPC1 | |
| SCHEMBL27838436 | 0.74 | GAA (0.46) | GAAPOLBMEN1NPC1RAB9A | |
| SCHEMBL31165993 | 0.73 | GAA (0.45) | GAAPOLBMEN1NPC1RAB9A | |
| SCHEMBL15758463 | 0.73 | RAB9A (0.46) | GAAPOLBKDM4EMEN1NPC1 | |
| SCHEMBL7908261 | 0.73 | GAA (0.45) | GAAPOLBMEN1NPC1RAB9A | |
| SCHEMBL27690459 | 0.73 | GAA (0.45) | GAAPOLBMEN1NPC1RAB9A | |
| SCHEMBL27938545 | 0.73 | GAA (0.45) | GAAPOLBMEN1NPC1RAB9A | |
| SCHEMBL30871486 | 0.72 | HDAC1 (0.42) | RAB9ATRPA1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102216276-A | substituted heteroaryl | PFIZER | 2011-10-12 | — | — | CN | disclosed |