Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052756 | 0.86 | L3MBTL1 (0.45) | TSHRALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3770522 | 0.82 | ALDH1A1 (0.43) | TSHRALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3778951 | 0.80 | ALDH1A1 (0.41) | TSHRALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3767006 | 0.79 | LMNA (0.51) | ALDH1A1KMT2AMEN1MAOBL3MBTL1 | |
| SCHEMBL27459179 | 0.79 | MEN1 (0.43) | KMT2AMEN1PRSS1TMPRSS15MAOB | |
| SCHEMBL27688160 | 0.78 | MEN1 (0.48) | KMT2AMEN1PRSS1TMPRSS15MAOB | |
| SCHEMBL26288558 | 0.77 | ALDH1A1 (0.43) | TSHRALDH1A1SMN1; SMN2KMT2AMMP8 | |
| SCHEMBL10708094 | 0.77 | PRSS1 (0.41) | KMT2AMEN1PRSS1TMPRSS15MAOB | |
| SCHEMBL2842757 | 0.77 | DPP4 (0.45) | TSHRALDH1A1SMN1; SMN2KMT2ACYP3A4 | |
| SCHEMBL6587934 | 0.76 | KMT2A (0.47) | TSHRALDH1A1SMN1; SMN2KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103342682-A | Intermediate for preparing pyrimidine derivatives | ASTRAZENECA AB | 2013-10-09 | — | — | CN | disclosed |
| CN-101925584-B | Pyrimidine Derivatives for the Treatment of Asthma, COPD, Allergic Rhinitis, Allergic Conjunctivitis, Atopic Dermatitis, Cancer, Hepatitis B, Hepatitis C, HIV, HPV, Bacterial Infections and Skin Diseases | ASTRAZENECA AB | 2013-04-17 | — | — | CN | disclosed |
| CN-101925584-A | Pyrimidine Derivatives for the Treatment of Asthma, COPD, Allergic Rhinitis, Allergic Conjunctivitis, Atopic Dermatitis, Cancer, Hepatitis B, Hepatitis C, HIV, HPV, Bacterial Infections and Skin Diseases | ASTRAZENECA AB | 2010-12-22 | — | — | CN | disclosed |