SCHEMBL278282

SCHEMBL278282

Cc1cc(Sc2ccccn2)cc(C(=O)ON2C(=O)CCC2=O)c1C

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GCK P35557 5/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
TSHR P16473 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
GAA P10253 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
NTRK1 P04629 2/20 0.35
LMNA P02545 1/20 0.34
ALDH1A1 P00352 1/20 0.34
EYA2 O00167 1/20 0.34
MGLL Q99685 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1679370 0.91 EHMT2 (0.35) GCKMEN1KMT2ACYP1A2CYP3A4
SCHEMBL1374041 0.82 GCK (0.39) GCKMEN1KMT2ACYP1A2CYP3A4
SCHEMBL278283 0.82 TSHR (0.36) MEN1KMT2ATSHRCYP1A2CYP3A4
SCHEMBL30392206 0.81 MEN1 (0.41) MEN1KMT2ATSHRCYP1A2CYP3A4
SCHEMBL28384909 0.81 MEN1 (0.41) MEN1KMT2ATSHRCYP1A2CYP3A4
SCHEMBL4184231 0.78 MEN1 (0.37) MEN1KMT2ATSHRCYP1A2CYP3A4
SCHEMBL73690 0.77 EHMT2 (0.37) MEN1KMT2ATSHRLMNAALDH1A1
SCHEMBL27193333 0.76 LMNA (0.37) MEN1KMT2ATSHRCYP1A2CYP3A4
SCHEMBL7112244 0.76 EHMT2 (0.35) MEN1KMT2ACYP1A2CYP3A4GAA
SCHEMBL4070360 0.75 LMNA (0.35) GCKMEN1KMT2ALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8133680-B2 affinity substrate comprises polydimethylsiloxane stamp alternately peptide-terminated or antibody terminated; WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-03-13 US disclosed
EP-1255996-B1 BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL ASSAY WISCONSIN ALUMNI RES FOUND (US) 2010-05-26 EP disclosed
US-7651662-B2 Rubbed substrate surfaces; activation; uniform anchoring of liquid crystals WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2010-01-26 US disclosed
EP-1668366-B1 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES WISCONSIN ALUMNI RES FOUND (US) 2008-01-09 EP disclosed
EP-1668366-A2 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2006-06-14 EP disclosed
US-20050260703-A1 Biochemical blocking layer for liquid crystal assay WISCONSIN ALUMNI RESEARCH FOUNDATION 2005-11-24 US disclosed
WO-2005080983-A2 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2005-09-01 WO disclosed
US-20050079486-A1 USING LIQUID CRYSTALS TO DETECT AFFINITY MICROCONTACT PRINTED BIOMOLECULES -, Wiscnsin Alumni Research Foundation (US) 2005-04-14 US disclosed
US-20040161800-A1 Biochemical blocking layer for liquid crystal assay WISCONSIN ALUMNI RESEARCH FOUNDATION 2004-08-19 US disclosed
US-6692699-B2 RUBBED SO THAT IT DRIVES UNIFORM ANCHORING OF LIQID CRYSTALS AND BONDS THE BIOMOLECULE RECOGNITION AGENT WISCONSIN ALUMNI RESEARCH FOUNDATION 2004-02-17 US disclosed
EP-1255996-A2 BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL ASSAY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2002-11-13 EP disclosed
US-20020055093-A1 Biochemical blocking layer for liquid crystal assay NATIONAL SCIENCE FOUNDATION 2002-05-09 US disclosed
WO-2001061325-A2 BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL ASSAY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2001-08-23 WO disclosed