Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784683 | 0.83 | FFAR1 (0.47) | LMNAKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL2781727 | 0.81 | RARB (0.45) | LMNAKMT2AMEN1HTTHPGD | |
| SCHEMBL2783032 | 0.80 | CXCR2 (0.47) | LMNAKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL2132234 | 0.77 | EPHX2 (0.55) | LMNAKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL2781686 | 0.77 | CYP1A2 (0.48) | LMNAKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL2780994 | 0.76 | HRH3 (0.40) | LMNAKMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL2780743 | 0.74 | TRPV1 (0.37) | — | |
| SCHEMBL2782718 | 0.73 | CYP1A2 (0.47) | CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2779102 | 0.73 | MRGPRX4 (0.47) | LMNAKMT2AMEN1HTTHPGD | |
| SCHEMBL2779974 | 0.70 | POLB (0.42) | TDP1LMNAHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136036-A2 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | claimed |
| WO-2010136036-A2 | CALCIUM-SENSING RECEPTOR-ACTIVE COMPOUNDS | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | disclosed |