Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4397330 | 0.89 | TSHR (0.61) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL538560 | 0.89 | SMN1; SMN2 (0.68) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1656572 | 0.88 | TSHR (0.51) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28160008 | 0.87 | ALDH1A1 (0.58) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10953526 | 0.87 | TSHR (0.57) | TSHRKDM4ESMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL1960348 | 0.87 | TSHR (0.50) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL11424711 | 0.87 | TSHR (0.57) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28794416 | 0.86 | TSHR (0.53) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL11455143 | 0.86 | SMN1; SMN2 (0.54) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28974979 | 0.85 | TSHR (0.74) | TSHRKDM4ELMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008322-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-104945311-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBVIE INC | 2015-09-30 | — | — | CN | disclosed |
| CN-102282128-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBVIE INC | 2015-06-17 | — | — | CN | disclosed |
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |
| CN-102282128-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | — | 2011-12-14 | — | — | CN | disclosed |