Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30553984 | 0.91 | HCRTR1 (0.65) | SLC6A3HCRTR1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL1989129 | 0.91 | HCRTR1 (0.65) | SLC6A3HCRTR1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL21986975 | 0.84 | HCRTR1 (0.58) | SLC6A3HCRTR1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4282830 | 0.82 | HCRTR1 (0.62) | SLC6A3HCRTR1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL5309541 | 0.82 | KMT2A (0.64) | SLC6A3SLC6A4L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL25794823 | 0.81 | TDP1 (0.62) | SLC6A3SLC6A4HCRTR1ALDH1A1MEN1 | |
| SCHEMBL16616127 | 0.79 | TDP1 (0.57) | SLC6A3SLC6A4L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL27413245 | 0.79 | HSP90AA1 (0.57) | SLC6A3SLC6A4L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL28178040 | 0.79 | HCRTR1 (0.58) | HCRTR1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7618555 | 0.79 | SLC6A3 (0.56) | SLC6A3HCRTR1L3MBTL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106008322-B | sulfonamide derivatives as BC L-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-106045893-A | Apoptosis-inducing agents for treatment of cancer and immune and autoimmune diseases | ABBVIE 公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-106008322-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102947285-B | Sulfonamide derivatives as BCL-2-selective apoptosis inducers for the treatment of cancer and immune diseases | ABBVIE (US) | 2015-08-26 | — | — | CN | disclosed |
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |
| CN-102282129-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | — | 2011-12-14 | — | — | CN | disclosed |