Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.53 |
| ▸ | GABRE | P78334 | 1/20 | 0.53 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.53 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.53 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.53 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11623477 | 0.84 | NNMT (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL11621514 | 0.80 | MAPT (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL28057187 | 0.80 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRKDM4ECYP3A4 | |
| SCHEMBL11619155 | 0.78 | NPC1 (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11617295 | 0.78 | TP53 (0.37) | ALDH1A1SMN1; SMN2KMT2AKDM4ERAB9A | |
| SCHEMBL11620038 | 0.76 | MAPT (0.38) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL30227675 | 0.76 | CTSB (0.44) | ALDH1A1SMN1; SMN2TSHRKDM4EHPGD | |
| SCHEMBL117763 | 0.76 | CTSB (0.44) | ALDH1A1SMN1; SMN2TSHRKDM4EHPGD | |
| SCHEMBL28029436 | 0.75 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL2729579 | 0.75 | MAPT (0.36) | ALDH1A1MEN1KMT2AKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307871-A | Isoindolinone and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-01-04 | — | — | CN | disclosed |