Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118706 | 0.74 | DPP4 (0.37) | ALDH1A1EPHX2EPHX1SMN1; SMN2RAB9A | |
| SCHEMBL7117796 | 0.71 | DPP4 (0.36) | ALDH1A1EPHX2EPHX1SMN1; SMN2RAB9A | |
| SCHEMBL7120600 | 0.70 | ALDH1A1 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL11037957 | 0.70 | ALDH1A1 (0.35) | ALDH1A1EPHX1MAPTKDM4EPOLB | |
| SCHEMBL28879161 | 0.69 | ALDH1A1 (0.39) | ALDH1A1EPHX2EPHX1SMN1; SMN2CYP3A4 | |
| SCHEMBL7115479 | 0.69 | HDAC3 (0.33) | ALDH1A1EPHX2EPHX1SMN1; SMN2RAB9A | |
| SCHEMBL28327457 | 0.69 | SIGMAR1 (0.41) | EPHX2EPHX1 | |
| SCHEMBL28327437 | 0.69 | SIGMAR1 (0.41) | EPHX2EPHX1 | |
| Succinic Acid SCHEMBL28239934 | 0.69 | ALDH1A1 (0.67) | ALDH1A1EPHX2EPHX1SMN1; SMN2RAB9A | |
| SCHEMBL14840177 | 0.68 | MAPT (0.45) | ALDH1A1EPHX2EPHX1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102516240-A | Heteroaryl-ureas and their use as glucokinase activators | NOVO NORDISK AS | 2012-06-27 | — | — | CN | disclosed |
| CN-1910166-B | Heteroaryl ureas and their use as glucokinase activators | NOVO NORDISK AS | 2012-01-04 | — | — | CN | disclosed |