Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | ATP4A | P20648 | 2/20 | 0.42 |
| ▸ | ATP4B | P51164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27897837 | 0.90 | GHSR (0.42) | CGASMAPTSMN1; SMN2ALPLHTT | |
| SCHEMBL27831429 | 0.89 | GRN (0.49) | SIRT2CGASNT5EMAPTSMN1; SMN2 | |
| SCHEMBL27897835 | 0.85 | MAPT (0.49) | CGASMAPTSMN1; SMN2HTTKDM4E | |
| SCHEMBL27851807 | 0.81 | MALT1 (0.49) | SIRT2NT5EATP4AATP4BMAPT | |
| SCHEMBL27851745 | 0.79 | CA12 (0.55) | SIRT2SMN1; SMN2ALDH1A1 | |
| SCHEMBL27706437 | 0.79 | SMN1; SMN2 (0.63) | MAPTSMN1; SMN2HTTPOLBALDH1A1 | |
| SCHEMBL27851691 | 0.78 | CA12 (0.47) | MAPTSMN1; SMN2POLBALDH1A1SMYD3 | |
| SCHEMBL28791614 | 0.78 | MAPT (0.40) | CGASATP4AATP4BMAPTSMN1; SMN2 | |
| SCHEMBL28791613 | 0.77 | SIRT2 (0.44) | SIRT2NT5EMAPTHTTALDH1A1 | |
| SCHEMBL27811122 | 0.76 | MAPT (0.47) | MAPTSMN1; SMN2ALPLHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102321074-B | Indole ring-substituted pyrazole hydrazide derivative and preparation method and application thereof | SHANDONG INST LIGHT INDUSTRY | 2013-04-10 | — | — | CN | claimed |
| CN-102321074-A | Indole ring-substituted pyrazole hydrazide derivative and preparation method and application thereof | SHANDONG INST LIGHT INDUSTRY | 2012-01-18 | — | — | CN | claimed |
| CN-102321074-B | Indole ring-substituted pyrazole hydrazide derivative and preparation method and application thereof | SHANDONG INST LIGHT INDUSTRY | 2013-04-10 | — | — | CN | disclosed |
| CN-102321074-A | Indole ring-substituted pyrazole hydrazide derivative and preparation method and application thereof | SHANDONG INST LIGHT INDUSTRY | 2012-01-18 | — | — | CN | disclosed |