Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 3/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GGT1 | P19440 | 2/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5288286 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTPTGS1SLC7A5GGT1 | |
| SCHEMBL202704 | 0.75 | — | — | |
| SCHEMBL13244968 | 0.75 | — | — | |
| SCHEMBL166753 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL19837180 | 0.72 | PTGS1 (0.46) | ALDH1A1MAPTPTGS1SLC7A5NOS2 | |
| SCHEMBL24489346 | 0.70 | PTGS1 (0.44) | ALDH1A1MAPTPTGS1SLC7A5 | |
| SCHEMBL11685771 | 0.70 | — | — | |
| SCHEMBL296273 | 0.70 | — | — | |
| SCHEMBL5299472 | 0.70 | — | — | |
| SCHEMBL17414698 | 0.70 | PTGS1 (0.44) | ALDH1A1MAPTPTGS1SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7778779-B2 | Method of identifying a chemical entity which is a hydroxylase modulator | ISIS INNOVATION LIMITED (GB) | 2010-08-17 | — | — | US | disclosed |
| EP-2156830-A1 | Modulators of asparaginyl hydoxylase activity of FIH | ISIS INNOVATION LIMITED (GB) | 2010-02-24 | — | — | EP | disclosed |
| EP-1554394-B1 | Screening methods using a structural model of FIH | ISIS INNOVATION (GB) | 2009-12-16 | — | — | EP | disclosed |
| US-20070048728-A1 | Hydroxylases and modulators thereof | ISIS INNOVATION LIMITED (GB) | 2007-03-01 | — | — | US | disclosed |
| EP-1554394-A2 | ASPARAGINYL HYDROXYLASES AND MODULATORS THEREOF | ISIS INNOVATION LIMITED (GB) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035812-A2 | ASPARAGINYL HYDROXYLASES AND MODULATORS THEREOF | ISIS INNOVATION LIMITED (GB) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070048728-A1 | Hydroxylases and modulators thereof | EGLN3, HIF1AN, EGLN2 | ALDH1A1 279/4885MAPT 4144/4885PTGS1 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.