Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 5/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27855565 | 0.76 | AADAT (0.36) | KDM4EHTR2CHTR2BHTR2AAKR1B1 | |
| SCHEMBL14070903 | 0.73 | HTR1A (0.36) | — | |
| SCHEMBL31040600 | 0.73 | MAOB (0.40) | HTR2CHTR2AAKR1B1L3MBTL1 | |
| SCHEMBL11123491 | 0.73 | HPGD (0.39) | AKR1B1 | |
| SCHEMBL11122122 | 0.73 | HPGD (0.42) | AKR1B1ALDH1A1 | |
| SCHEMBL12216130 | 0.70 | ELANE (0.35) | KDM4E | |
| SCHEMBL834241 | 0.69 | ALDH2 (0.37) | KDM4EAKR1B1ALDH1A1L3MBTL1 | |
| SCHEMBL32673059 | 0.69 | TSHR (0.37) | KDM4EAKR1B1 | |
| SCHEMBL28587199 | 0.69 | HPGD (0.41) | KDM4ECRBNAKR1B1ALDH1A1 | |
| SCHEMBL16283615 | 0.69 | PTGS1 (0.41) | AKR1B1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102245587-A | Trpv1 antagonists | ABBOTT LAB | 2011-11-16 | — | — | CN | disclosed |
| CN-102186836-A | Trpv1 antagonists | ABBOTT LAB | 2011-09-14 | — | — | CN | disclosed |