Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.42 |
| ▸ | PPARG | P37231 | 7/20 | 0.42 |
| ▸ | PPARD | Q03181 | 7/20 | 0.42 |
| ▸ | PPARA | Q07869 | 7/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6554853 | 0.97 | LMNA (0.50) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL27654619 | 0.95 | LMNA (0.48) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL3690204 | 0.84 | AKR1B1 (0.62) | LMNASLC22A6TSHRAKR1B1GPR84 | |
| Sebacic Acid SCHEMBL28729977 | 0.82 | GPR84 (0.64) | LMNASLC22A6TSHRAKR1B1GPR84 | |
| SCHEMBL381203 | 0.82 | LMNA (0.50) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL2331455 | 0.81 | — | — | |
| SCHEMBL2427620 | 0.80 | LMNA (0.48) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL7086369 | 0.80 | LMNA (0.48) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL1572851 | 0.79 | LMNA (0.53) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL14359877 | 0.79 | TDP1 (0.54) | LMNASLC22A6TSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007118-B | Pyrrolidinone glucokinase activators | HOFFMANN LA ROCHE | 2014-12-31 | — | — | CN | disclosed |
| CN-102007118-A | Pyrrolidinone glucokinase activators | HOFFMANN LA ROCHE | 2011-04-06 | — | — | CN | disclosed |