Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784293 | 0.91 | LMNA (0.34) | LMNAOPRK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2781291 | 0.90 | OPRK1 (0.32) | OPRK1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL10266681 | 0.89 | OPRK1 (0.33) | LMNAOPRK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL620357 | 0.89 | MEN1 (0.35) | LMNAOPRK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL622269 | 0.84 | ALDH1A1 (0.36) | LMNAOPRK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2781796 | 0.84 | LMNA (0.37) | LMNAOPRK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2784968 | 0.84 | IKBKB (0.37) | LMNAOPRK1ALDH1A1SMN1; SMN2GABRA1 | |
| SCHEMBL2778625 | 0.84 | LMNA (0.37) | LMNAOPRK1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2781073 | 0.82 | LMNA (0.32) | LMNAOPRK1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2785428 | 0.81 | LMNA (0.36) | LMNAOPRK1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139322-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | Smithkline Beecham Corporation (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118724-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |