Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.55 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 2/20 | 0.46 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.46 |
| ▸ | MARK3 | P27448 | 2/20 | 0.46 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | SIK1 | P57059 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.46 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.46 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27844447 | 0.93 | AURKA (0.47) | TBK1JAK3EGFRCDK1KDR | |
| SCHEMBL1284581 | 0.92 | TBK1 (0.54) | TBK1JAK3EGFRCDK1KDR | |
| SCHEMBL1284997 | 0.85 | TBK1 (0.47) | TBK1JAK3EGFRCDK1KDR | |
| SCHEMBL1285268 | 0.85 | AURKA (0.46) | TBK1JAK3EGFRCDK1KDR | |
| SCHEMBL27825347 | 0.83 | CDK4 (0.46) | TBK1JAK3EGFRCDK1KDR | |
| SCHEMBL27825349 | 0.83 | MAP3K5 (0.47) | JAK3EGFRAURKACDK4 | |
| SCHEMBL28793682 | 0.82 | CDK4 (0.46) | TBK1JAK3EGFRCDK1KDR | |
| SCHEMBL28793684 | 0.81 | MAP3K5 (0.47) | JAK3EGFRAURKACDK4 | |
| SCHEMBL1284577 | 0.80 | HDAC3 (0.47) | TBK1JAK3EGFRCDK2CCNA2 | |
| SCHEMBL28793685 | 0.78 | AURKA (0.39) | TBK1JAK3EGFRCDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | claimed |
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | disclosed |