Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27825349 | 0.98 | MAP3K5 (0.47) | MAP3K5ABL1PDGFRBSRCPDGFRA | |
| SCHEMBL1285497 | 0.91 | MAP3K5 (0.46) | MAP3K5ABL1PDGFRBSRCPDGFRA | |
| SCHEMBL1284750 | 0.89 | MAP3K5 (0.46) | MAP3K5ABL1PDGFRBSRCPDGFRA | |
| SCHEMBL28793682 | 0.89 | CDK4 (0.46) | SRCAURKACDK4EGFRCSNK2A1 | |
| SCHEMBL27825347 | 0.87 | CDK4 (0.46) | SRCAURKACDK4EGFRCSNK2A1 | |
| SCHEMBL27844447 | 0.83 | AURKA (0.47) | SRCAURKACDK4EGFRCSNK2A1 | |
| SCHEMBL28793685 | 0.82 | AURKA (0.39) | SRCAURKACDK4EGFRCSNK2A1 | |
| SCHEMBL27844363 | 0.81 | TBK1 (0.55) | AURKACDK4EGFRJAK3 | |
| SCHEMBL1285070 | 0.80 | CDK4 (0.45) | SRCAURKACDK4EGFRCSNK2A1 | |
| SCHEMBL27825343 | 0.80 | CAMK2D (0.40) | AURKACDK4EGFRCCNT1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | claimed |
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | disclosed |