Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 7/20 | 0.37 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | LYN | P07948 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | ROS1 | P08922 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1284716 | 0.92 | AURKA (0.38) | AURKACDK4JAK3JAK2EGFR | |
| SCHEMBL27844373 | 0.91 | SYK (0.45) | JAK3JAK2SYKTYK2IRAK4 | |
| SCHEMBL27825347 | 0.84 | CDK4 (0.46) | AURKACDK4JAK3JAK2EGFR | |
| SCHEMBL27825349 | 0.83 | MAP3K5 (0.47) | AURKACDK4JAK3EGFRSRC | |
| SCHEMBL28793682 | 0.82 | CDK4 (0.46) | AURKACDK4JAK3JAK2EGFR | |
| SCHEMBL1285133 | 0.82 | SYK (0.46) | CDK4JAK3JAK2SYKCDK1 | |
| SCHEMBL28793684 | 0.82 | MAP3K5 (0.47) | AURKACDK4JAK3EGFRSRC | |
| SCHEMBL27844447 | 0.80 | AURKA (0.47) | AURKACDK4JAK3JAK2EGFR | |
| SCHEMBL27844363 | 0.78 | TBK1 (0.55) | AURKACDK4JAK3JAK2EGFR | |
| SCHEMBL1284577 | 0.76 | HDAC3 (0.47) | CDK4JAK3JAK2EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | claimed |
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | disclosed |