Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.39 |
| ▸ | FEN1 | P39748 | 9/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 5/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784158 | 0.85 | CACNA1B (0.39) | CACNA1BPIK3CDPGRNR3C1NR3C2 | |
| SCHEMBL2786310 | 0.80 | PGR (0.46) | ALOX5APFEN1PIK3CDPGR | |
| SCHEMBL3019210 | 0.79 | PGR (0.55) | CACNA1BPIK3CDPGRNR3C1NR3C2 | |
| SCHEMBL8052840 | 0.79 | PGR (0.55) | CACNA1BPIK3CDPGRNR3C1NR3C2 | |
| SCHEMBL2786152 | 0.77 | GRIN1 (0.40) | PIK3CDPGR | |
| SCHEMBL3042679 | 0.75 | PIK3CA (0.36) | ALOX5APFEN1CACNA1BPIK3CDPGR | |
| SCHEMBL2786464 | 0.75 | PGR (0.39) | PIK3CDPGRNR3C1NR3C2AR | |
| SCHEMBL2785852 | 0.75 | PGR (0.41) | PIK3CDPGRNR3C1NR3C2AR | |
| SCHEMBL2784455 | 0.74 | PGR (0.40) | PIK3CDPGRNR3C1NR3C2AR | |
| SCHEMBL1949443 | 0.74 | CACNA1B (0.42) | CACNA1BPIK3CDPGRNR3C1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |