Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785052 | 0.90 | PIK3CD (0.40) | GRIN1GRIN2BPIK3CDPGREPHX2 | |
| SCHEMBL2784158 | 0.80 | CACNA1B (0.39) | GRIN1GRIN2BPIK3CDPGREPHX2 | |
| SCHEMBL2784455 | 0.80 | PGR (0.40) | GRIN1GRIN2BPIK3CDPGR | |
| SCHEMBL8066741 | 0.80 | PGR (0.53) | GRIN1GRIN2BPIK3CDPGREPHX2 | |
| SCHEMBL2784159 | 0.79 | PIK3CD (0.40) | PIK3CDPGREPHX2PIK3R1 | |
| SCHEMBL2787297 | 0.77 | PGR (0.49) | GRIN1GRIN2BPIK3CDPGR | |
| SCHEMBL2784931 | 0.77 | ALOX5AP (0.39) | PIK3CDPGR | |
| SCHEMBL2786610 | 0.74 | HDAC1 (0.38) | GRIN1GRIN2BPIK3CDPGR | |
| SCHEMBL2785774 | 0.73 | HDAC1 (0.37) | PIK3CDPGRPIK3R1 | |
| SCHEMBL3033244 | 0.73 | GRIN1 (0.41) | GRIN1GRIN2BPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | disclosed |