Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957162 | 0.85 | CYP2C9 (0.47) | KMT2ACYP2C9CYP2C19MAPTMEN1 | |
| Bromobenzene SCHEMBL28102861 | 0.83 | KMT2A (0.48) | KMT2ACYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL17893779 | 0.76 | HIF1A (0.50) | KMT2ACYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL2540179 | 0.76 | CTNNB1 (0.62) | KMT2AMAPTMEN1HSD17B10MAPK1 | |
| SCHEMBL7715935 | 0.76 | MYC (0.54) | KMT2AMAPTMEN1ALDH1A1TSHR | |
| SCHEMBL8782253 | 0.75 | SLC6A3 (0.61) | KMT2AMAPTMEN1ALDH1A1TSHR | |
| SCHEMBL27850308 | 0.75 | SLC6A3 (0.64) | KMT2ACYP2C19MEN1ALDH1A1TSHR | |
| SCHEMBL432 | 0.75 | MEN1 (0.56) | KMT2ACYP2C9CYP2C19MAPTMEN1 | |
| SCHEMBL1359510 | 0.75 | ALDH1A1 (0.65) | KMT2AMAPTMEN1ALDH1A1TSHR | |
| SCHEMBL17535526 | 0.75 | TDP1 (0.51) | KMT2ACYP2C9CYP2C19MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307872-B | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBVIE 公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-102947285-A | Sulfonamide derivatives as BCL-2-selective apoptosis inducers for the treatment of cancer and immune diseases | ABBOTT LAB | 2013-02-27 | — | — | CN | disclosed |
| CN-102307872-A | BCL-2-selectively apoptosis-inducing agents for the treatment of cancer and immune diseases | ABBOTT LAB | 2012-01-04 | — | — | CN | disclosed |