Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propene SCHEMBL7714959 | 0.93 | MYC (0.48) | MYCSMN1; SMN2KMT2AL3MBTL1POLB | |
| SCHEMBL23708768 | 0.85 | NPC1 (0.60) | MYCSMN1; SMN2KMT2AL3MBTL1POLB | |
| SCHEMBL5742226 | 0.83 | MYC (0.55) | MYCSMN1; SMN2KMT2AL3MBTL1MEN1 | |
| SCHEMBL29232403 | 0.81 | MYC (0.54) | MYCSMN1; SMN2KMT2AL3MBTL1POLB | |
| SCHEMBL7743758 | 0.81 | GAA (0.59) | MYCKMT2APOLBMEN1TSHR | |
| SCHEMBL112024 | 0.81 | ADRB1 (0.55) | MYCSMN1; SMN2KMT2AL3MBTL1MEN1 | |
| SCHEMBL16055267 | 0.81 | CYP1A2 (0.40) | MYCSMN1; SMN2KMT2AL3MBTL1LMNA | |
| SCHEMBL16056417 | 0.81 | KMT2A (0.39) | MYCSMN1; SMN2KMT2AL3MBTL1POLB | |
| SCHEMBL17893724 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL30109558 | 0.81 | PRMT5 (0.54) | MYCSMN1; SMN2KMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |
| EP-1023068-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1023068-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1998057638-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |