Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 5/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27869088 | 0.91 | CFTR (0.32) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL27852003 | 0.83 | MAPT (0.34) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL1118042 | 0.82 | PIK3CG (0.38) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL1782768 | 0.78 | HCAR3 (0.43) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL27857568 | 0.77 | PI4KA (0.33) | SMN1; SMN2RAB9ANPC1LMNAMAPT | |
| SCHEMBL1770958 | 0.76 | ABL1 (0.34) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL691255 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL13690398 | 0.76 | PIK3CA (0.43) | LMNAMAPTGAAHPGDPIK3CG | |
| SCHEMBL1781491 | 0.75 | PIK3CG (0.42) | SMN1; SMN2TP53RAB9AALDH1A1NPC1 | |
| SCHEMBL1783767 | 0.75 | PIK3CG (0.39) | LMNAMAPTGAAHPGDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459282-A | Thia-triaza-cyclopentazulenes as PI 3-kinase inhibitors for the treatment of cancer | BOEHRINGER INGELHEIM INT | 2012-05-16 | — | — | CN | disclosed |