Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20640264 | 0.83 | OPRM1 (0.40) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL16908880 | 0.83 | FPR2 (0.40) | OPRM1OPRD1MEN1KMT2AGAA | |
| SCHEMBL28042117 | 0.83 | EGFR (0.39) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL24112626 | 0.81 | SLC6A4 (0.43) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL4699835 | 0.79 | AKR1C1 (0.45) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL23878152 | 0.76 | HDAC3 (0.34) | HDAC4 | |
| SCHEMBL2572169 | 0.76 | AKR1C1 (0.42) | OPRM1OPRL1OPRD1OPRK1MEN1 | |
| SCHEMBL6938953 | 0.75 | OPRM1 (0.45) | OPRM1OPRL1OPRD1OPRK1KMT2A | |
| SCHEMBL28398971 | 0.75 | OPRM1 (0.65) | OPRM1OPRD1OPRK1MEN1KMT2A | |
| SCHEMBL16908889 | 0.75 | CA1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104262294-A | N- (1, 1, 1, 3, 3, 3-hexafluoro-2-hydroxypropan-2-yl) Benzyl-n' -arylcarbonylpiperaz Ine Derivatives | ORGANON NV | 2015-01-07 | — | — | CN | disclosed |
| CN-102026986-B | Hexafluoroisopropanol derivatives | MERCK SHARP & DOHME B.V. (NL) | 2014-10-29 | — | — | CN | disclosed |
| CN-102026986-A | Hexafluoroisopropanol derivatives | ORGANON NV | 2011-04-20 | — | — | CN | disclosed |