Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674529 | 0.84 | KMT2A (0.45) | FPR2MAPK1HDAC1MEN1KMT2A | |
| SCHEMBL27853655 | 0.83 | OPRM1 (0.41) | MAPK1MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL11553511 | 0.81 | DRD2 (0.38) | MAPK1HDAC1MEN1KMT2ACA1 | |
| SCHEMBL4697560 | 0.79 | CA1 (0.38) | MAPK1HDAC1CA1CA2LMNA | |
| SCHEMBL27788488 | 0.78 | KMT2A (0.43) | FPR2MAPK1HDAC1MEN1KMT2A | |
| SCHEMBL20790320 | 0.78 | HDAC1 (0.45) | HDAC1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2720401 | 0.77 | CA1 (0.37) | FPR2MAPK1HDAC1MEN1KMT2A | |
| SCHEMBL19029456 | 0.76 | HDAC6 (0.33) | HDAC1ALDH1A1 | |
| SCHEMBL16908889 | 0.75 | CA1 (0.40) | CA1CA2 | |
| SCHEMBL27970983 | 0.75 | ALDH1A1 (0.39) | MAPK1HDAC1MEN1KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552206-B1 | TRICYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE INC (JP) | 2015-07-22 | — | — | EP | disclosed |