Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27836764 | 0.86 | CNR1 (0.42) | CNR2CNR1TLR8ALOX5PTGS2 | |
| SCHEMBL27854790 | 0.83 | HTT (0.47) | CNR2NPC1RAB9ACYP1A2MAPT | |
| SCHEMBL27742966 | 0.81 | CNR1 (0.61) | CNR2NPC1RAB9ACYP1A2MAPT | |
| SCHEMBL4054662 | 0.81 | CNR1 (0.45) | CNR2NPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL27836801 | 0.81 | CNR2 (0.45) | CNR2NPC1RAB9AMAPTHPGD | |
| SCHEMBL27742971 | 0.80 | ALOX5 (0.43) | CNR2SMN1; SMN2CNR1HTTALOX5 | |
| SCHEMBL27938671 | 0.80 | CNR1 (0.44) | CNR2RAB9AHPGDSMN1; SMN2CNR1 | |
| SCHEMBL27742975 | 0.79 | CNR1 (0.43) | CNR2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL27639476 | 0.79 | CNR2 (0.43) | CNR2NPC1RAB9ACYP1A2MAPT | |
| SCHEMBL27639471 | 0.79 | CNR1 (0.43) | CNR2NPC1RAB9ACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102026985-A | Quinazoline derivatives as RAF kinase modulators and methods and uses thereof | AMBIT BIOSCIENCES CORPORATON | 2011-04-20 | — | — | CN | disclosed |