Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.37 |
| ▸ | GOT1 | P17174 | 1/20 | 0.37 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.37 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842654 | 0.77 | NOTUM (0.38) | AADATGOT1KYAT1KYAT3NOTUM | |
| SCHEMBL17652448 | 0.74 | MAPT (0.37) | NOTUMLMNAMAPTHTTMAPK1 | |
| SCHEMBL28752315 | 0.73 | ACE (0.46) | — | |
| SCHEMBL27629185 | 0.73 | LMNA (0.38) | AADATGOT1NOTUMLMNAALDH1A1 | |
| SCHEMBL28317897 | 0.73 | NOTUM (0.38) | AADATGOT1KYAT1KYAT3NOTUM | |
| SCHEMBL28491796 | 0.70 | CHRM2 (0.41) | AADATGOT1KYAT1KYAT3NOTUM | |
| SCHEMBL28735654 | 0.69 | NOTUM (0.36) | AADATGOT1KYAT1KYAT3NOTUM | |
| SCHEMBL4275949 | 0.69 | NOTUM (0.49) | NOTUMALDH1A1CYP2C19 | |
| SCHEMBL7554141 | 0.69 | NOTUM (0.49) | NOTUMALDH1A1CYP2C19 | |
| SCHEMBL27383076 | 0.69 | ACE (0.39) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102351777-B | Preparation method for chiral 3-hydroxyl-3-methylene nitro indole-2-ketone derivative | UNIV SOOCHOW | 2014-03-19 | — | — | CN | claimed |
| CN-102351777-A | Preparation method for chiral 3-hydroxyl-3-methylene nitro indole-2-ketone derivative | UNIV SOOCHOW | 2012-02-15 | — | — | CN | claimed |
| CN-102351777-B | Preparation method for chiral 3-hydroxyl-3-methylene nitro indole-2-ketone derivative | UNIV SOOCHOW | 2014-03-19 | — | — | CN | disclosed |
| CN-102351777-A | Preparation method for chiral 3-hydroxyl-3-methylene nitro indole-2-ketone derivative | UNIV SOOCHOW | 2012-02-15 | — | — | CN | disclosed |