Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 12/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 12/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.77 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | PKM | P14618 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831728 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL19632954 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL45924 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL2785528 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL13171965 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL29265327 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL2785024 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL3831721 | 1.00 | OPRD1 (1.00) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL16445250 | 0.97 | OPRD1 (0.93) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 | |
| SCHEMBL19181060 | 0.97 | OPRD1 (0.93) | OPRD1OPRM1OPRK1CYP2D6CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170095469-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2017-04-06 | — | — | US | disclosed |
| EP-2190819-B1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECH INST (US) | 2016-05-25 | — | — | EP | disclosed |
| US-20140107143-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2014-04-17 | — | — | US | disclosed |
| US-8563572-B2 | Quaternary opioid carboxamides | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120302594-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2012-11-29 | — | — | US | disclosed |
| US-8263807-B2 | Quaternary opioid carboxamides | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2012-09-11 | — | — | US | disclosed |
| EP-2190819-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2010-06-02 | — | — | EP | disclosed |
| US-20090197905-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2009-08-06 | — | — | US | disclosed |
| WO-2009023567-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2009-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095469-A1 | QUATERNARY OPIOID CARBOXAMIDES | OPRK1, OPRM1, OPRD1 | OPRD1 3/4885OPRM1 2/4885OPRK1 1/4885 |
| US-20140107143-A1 | QUATERNARY OPIOID CARBOXAMIDES | OPRK1, OPRM1, OPRD1 | OPRD1 3/4885OPRM1 2/4885OPRK1 1/4885 |
| US-20090197905-A1 | QUATERNARY OPIOID CARBOXAMIDES | OPRK1, OPRM1, OPRD1 | OPRD1 3/4885OPRM1 2/4885OPRK1 1/4885 |
| US-20120302594-A1 | QUATERNARY OPIOID CARBOXAMIDES | OPRK1, OPRM1, OPRD1 | OPRD1 3/4885OPRM1 2/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.