SCHEMBL27856470

SCHEMBL27856470

O=Cc1ncnn1-c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.41
KDM4C Q9H3R0 1/20 0.40
HTT P42858 4/20 0.40
ALDH1A1 P00352 7/20 0.39
LMNA P02545 3/20 0.39
P2RX7 Q99572 1/20 0.38
KDM4E B2RXH2 2/20 0.37
CYP1A2 P05177 2/20 0.37
CYP2C19 P33261 2/20 0.37
KMT2A Q03164 2/20 0.37
GAA P10253 1/20 0.37
MEN1 O00255 1/20 0.37
EGFR P00533 1/20 0.37
TSHR P16473 1/20 0.37
PI4KA P42356 1/20 0.37
PI4K2B Q8TCG2 1/20 0.37
HSD17B10 Q99714 1/20 0.37
PI4K2A Q9BTU6 1/20 0.37
PI4KB Q9UBF8 1/20 0.37
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27857905 0.81 NPC1 (0.41) ALDH1A1LMNAKDM4EATMMAPT
SCHEMBL27958684 0.79 ALDH1A1 (0.38) ALDH1A1KDM4ESMN1; SMN2NPSR1
SCHEMBL27857906 0.75 MGLL (0.37) P2RX7
SCHEMBL27858047 0.75 KCNN4 (0.42) LMNAKDM4EKMT2AMEN1PI4KA
SCHEMBL27840291 0.75 P2RX7 (0.44) P2RX7GAA
SCHEMBL27840275 0.75 MGLL (0.37) P2RX7MAPT
SCHEMBL27950665 0.74 POLB (0.37) POLBALDH1A1LMNAKDM4EKMT2A
SCHEMBL27857908 0.72 P2RX7 (0.34) P2RX7KDM4ESMN1; SMN2
SCHEMBL8390054 0.70 ATM (0.35) ALDH1A1ATM
SCHEMBL10166462 0.69 MAPK1 (0.41) POLBHTTALDH1A1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103881389-B Addition curable self-adhesive silicone rubber composition 信越化学工业株式会社 2018-04-10 CN disclosed
CN-107001800-A Addition-curable silicon rubber composition 信越化学工业株式会社 2017-08-01 CN disclosed
CN-103180489-B Electrodeposition coatings containing lanthanide elements for use on aluminum substrates PPG INDUSTRIES OHIO, INC. (US) 2016-03-16 CN disclosed
CN-103582678-B The method of protection transparent, non-metallic conductive component DOW CORNING TORAY CO.,LTD. (JP) 2016-01-20 CN disclosed
CN-102369246-B Method for treating and/or coating a substrate with a chromium-free material PRC DESOTO INT INC 2014-07-30 CN disclosed
CN-103881389-A Addition curable self-adhesive silicone rubber composition SHINETSU CHEMICAL CO 2014-06-25 CN disclosed
CN-103582678-A Method of protecting transparent nonmetallic electroconductive parts DOW CORNING TORAY CO LTD 2014-02-12 CN disclosed
CN-102250024-B Preparation method of 1-substituted-4-carbamoyl-1,2,4-triazol-5-one derivatives HOKKO CHEM IND CO 2014-01-29 CN disclosed
CN-103180489-A Electrodeposition coatings containing lanthanide elements for use on aluminum substrates PPG IND OHIO INC 2013-06-26 CN disclosed
CN-102369246-A Method for treating and/or coating a substrate with a chromium-free material PRC DESOTO INT INC 2012-03-07 CN disclosed
CN-102250024-A Preparation method of 1-substituted-4-carbamoyl-1,2,4-triazol-5-one derivatives HOKKO CHEM IND CO 2011-11-23 CN disclosed