Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 17/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14355084 | 0.79 | CYP11B1 (0.45) | WNT3A | |
| SCHEMBL3423338 | 0.79 | CCR1 (0.56) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27861151 | 0.79 | DYRK1A (0.58) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1492636 | 0.76 | MAP4K4 (0.50) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18015428 | 0.76 | MAP4K4 (0.43) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22886741 | 0.76 | DYRK1A (0.44) | WNT3APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28719887 | 0.75 | WNT3A (0.46) | WNT3A | |
| SCHEMBL3152503 | 0.75 | CCR1 (0.46) | — | |
| SCHEMBL6673320 | 0.75 | AURKA (0.55) | — | |
| SCHEMBL10033044 | 0.73 | WNT3A (0.45) | WNT3AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104379583-B | Compounds and compositions as WNT signaling inhibitors and uses thereof | 广州源生医药科技有限公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-102558173-A | Compound for inhibiting WNT signal transduction, composition and application thereof | GUANGZHOU YUANSHENG PHARMACEUTICAL SCIENCES & TECHNOLOGY CO LTD | 2012-07-11 | — | — | CN | disclosed |