Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786152 | 0.90 | GRIN1 (0.40) | PIK3CDPIK3R1EPHX2PGRGRIN1 | |
| SCHEMBL2784159 | 0.89 | PIK3CD (0.40) | PIK3CDHDAC1HDAC8HDAC6PIK3R1 | |
| SCHEMBL2784455 | 0.78 | PGR (0.40) | PIK3CDHDAC1HDAC8HDAC6PGR | |
| SCHEMBL3023025 | 0.78 | EPHX2 (0.53) | PIK3CDHDAC1HDAC8HDAC6PIK3R1 | |
| SCHEMBL2787297 | 0.77 | PGR (0.49) | PIK3CDPGRGRIN1GRIN2B | |
| SCHEMBL2784158 | 0.76 | CACNA1B (0.39) | PIK3CDEPHX2PGRGRIN1GRIN2B | |
| SCHEMBL2786610 | 0.76 | HDAC1 (0.38) | PIK3CDHDAC1HDAC8HDAC6PGR | |
| SCHEMBL2787876 | 0.73 | HDAC1 (0.35) | PIK3CDHDAC1HDAC8HDAC6PIK3R1 | |
| SCHEMBL2785774 | 0.73 | HDAC1 (0.37) | PIK3CDHDAC1HDAC8HDAC6PIK3R1 | |
| SCHEMBL2784931 | 0.73 | ALOX5AP (0.39) | PIK3CDPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |