Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL27863894 | 1.00 | KMT2A (0.53) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Styrene SCHEMBL9615577 | 0.84 | MEN1 (0.50) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Styrene SCHEMBL27543957 | 0.84 | DNM1 (0.53) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Styrene SCHEMBL9615584 | 0.84 | MEN1 (0.50) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Styrene SCHEMBL28207868 | 0.83 | DNM1 (0.52) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Styrene SCHEMBL9615086 | 0.82 | DNM1 (0.77) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Styrene SCHEMBL28204232 | 0.82 | ALDH1A1 (0.56) | KMT2AMEN1MAPK1TP53CHRM2 | |
| Hydrochloric Acid SCHEMBL8816571 | 0.82 | HTT (0.58) | KMT2AHTTDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL3029861 | 0.82 | HTT (0.58) | KMT2AHTTDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL10492694 | 0.82 | HTT (0.58) | KMT2AHTTDNM1HSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102580570-A | Immobilized Ag<+> facilitated transport membrane as well as preparation method and application thereof | UNIV ZHEJIANG GONGSHANG | 2012-07-18 | — | — | CN | claimed |
| CN-102580570-A | Immobilized Ag<+> facilitated transport membrane as well as preparation method and application thereof | UNIV ZHEJIANG GONGSHANG | 2012-07-18 | — | — | CN | disclosed |