Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | S100A4 | P26447 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029915 | 0.72 | S100A4 (0.46) | TDP1S100A4LMNACA1CA2 | |
| SCHEMBL2030956 | 0.70 | CA1 (0.48) | TDP1S100A4LMNACA1CA2 | |
| SCHEMBL3039191 | 0.65 | TDP1 (0.67) | TDP1S100A4CA1CA2CA7 | |
| SCHEMBL1613571 | 0.63 | S100A4 (0.46) | TDP1S100A4LMNACA1CA2 | |
| SCHEMBL516272 | 0.62 | LMNA (0.58) | TDP1S100A4LMNACA1CA2 | |
| SCHEMBL30708932 | 0.62 | LMNA (0.58) | TDP1S100A4LMNACA1CA2 | |
| SCHEMBL472112 | 0.61 | TDP1 (1.00) | TDP1S100A4LMNATSHRSMN1; SMN2 | |
| SCHEMBL6051840 | 0.60 | TSHR (0.69) | TDP1S100A4LMNACA1CA2 | |
| SCHEMBL2524312 | 0.60 | TDP1 (0.58) | TDP1S100A4LMNATSHRSMN1; SMN2 | |
| SCHEMBL9397167 | 0.60 | S100A4 (0.59) | TDP1S100A4LMNACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102448955-B | Aminopyrimidine Anticancer Compounds | OSI PHARM INC | 2014-06-18 | — | — | CN | disclosed |
| CN-102448955-A | Aminopyrimidine Anticancer Compounds | OSI PHARM INC | 2012-05-09 | — | — | CN | disclosed |